Background: It is unclear how retinal ischemia influences the changes of visual acuity, macular sensitivity, macular\r\nthickness, and macular volume after the performance of pars plana vitrectomy (PPV) for macular edema in patients\r\nwith central retinal vein occlusion (CRVO).\r\nMethods: Ten patients (10 eyes) with CRVO and macular edema underwent PPV. Retinal ischemia was evaluated\r\nfrom the area of capillary nonperfusion on fluorescein angiography, and the patients were classified into ischemic\r\nor nonischemic groups. Microperimetry was performed with a Micro Perimeter 1. Macular thickness and volume\r\nwere measured by optical coherence tomography.\r\nResults: In both groups, the mean macular thickness within the central 4�°, 10�°, and 20�° fields decreased significantly\r\nfrom baseline to 3 and 6 months after PPV (all P < 0.05). In the ischemic group, the mean macular sensitivity within\r\nthe central 4�°, 10�°, and 20�° fields increased from baseline to 3 and 6 months after PPV, but no significant difference\r\nwas observed.\r\nConclusions: These results suggest that PPV may be effective for improving macular thickness, volume, and sensitivity\r\nin patients with macular edema secondary to ischemic CRVO, although there was no significant difference.
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